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So, for studies with K treatment arms and a single control arm, K+1 coefficients are used to capture FTO effects on within arm change scores (set 1), and K coefficients are used to capture FTO effects on treatment versus control differences in change scores (set 2). Importantly, the first set of coefficients is estimated from separate groups of study participants, rendering them statistically independent and facilitating standard error calculations for the second set of coefficients that capture the interaction effects of gene x treatment. However, the second set of coefficients uses a common control group for each study, which introduces dependence at the study level.This second set of regression coefficients from table 2 was used to evaluate differences in FTO allelic effects on the outcomes of interest between intervention and control groups.

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